Immunomediated Diseases and Innovative Therapies

Overview

The Immunomediated Diseases and Innovative Therapies is a heterogeneous area composed by both translational and clinical research groups which cover fields such as immunology, respiratory and systemic diseases, pharmacology, clinical biochemistry, rheumatology, advanced therapies or transfusional medicine. Its main strength derives precisely from this heterogeneity and the complementarity of the scientific interests and expertise of the different groups, many of which are currently joining efforts and synergizing in a variety of collaborative research projects.

Publications

229

total

1430

impact factor

6.25

average impact factor

Group Leader: Ricardo Pujol Borrell

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The main contributions were the generation of the first set of reference values ??for deep immunophenotyping in children and of one of the first analyses on the efficiency of NGS for the diagnosis of Primary Immunodeficiencies (PID). In a concerted action with the IIPP group, it became the reference team for cases detected in the neonatal screening for PID. Regarding Autoimmunity, in collaboration with the systemic autoimmune diseases group, the role of given autoantibodies as biomarkers was analyzed and the quest for new biomarkers, continued. In thyroid autoimmunity stands out the demonstration of PD-L1 in thyrocytes that led to a reformulation of one of the contending hypotheses in autoimmunity. The analysis of the relationship of TSHR genotypes and isoform expression, was the basis for a new proposal on the mechanisms of anti-TSHR receptor antibodies generation in Graves’ disease. These results lead to new projects and alliance with front-line international research groups.

17

total

97

impact factor

5^.68

average impact factor

SELECTED ARTICLES

Mensa-Vilaró A, Bravo García-Morato M, de la Calle-Martin O, Franco-Jarava C, Martínez-Saavedr MT, González-Granado LI, González-Roca E, Fuster J L., Alsina L, Mutchinick OM, Balderrama-Rodríguez A, Ramos E, Modesto, C, Mesa-del-Castillo, P, Ortego-Centeno, N, Clemente, D, Souto A, Palmou, N, Remesal A., Leslie KS, Gómez de la Fuente E, Bravo Gallego LY, Campistol JM, Guirat Dhouib N, Bejaoui M, Almeida Dutra L, Terreri MT, Mosquera C, González T, Cañellas J, García-Ruiz de Morales, Wouters CH, Bosque MT, Cham WT,i Jiméenez-Treviño S, de Inocencio J, Bloomfield M, Pérez de Diego R Martínez-Pomar N, Rodrí?guez-Pena R, González-Santesteban C, Soler-Palacín P, Casals F, Yague J, Allende L, Rodríguez-Gallego JC, Colobran R, Martí?nez-Martí?nez L, López-Granados E, Aróstegui, JI.
Unexpected relevant role of gene mosaicism in patients with primary immunodeficiency diseases.
J Allergy Clin Immunol. 2019 Jan;143(1):359-368
doi.org/10.1016/j.jaci.2018.09.009
IF: 14.11
Lorente-Sorolla C., Garcia-Gomez, A., Català-Moll, F., Toledano, V., Ciudad, L., Avendaño-Ortiz, J., Maroun-Eid, C., Martín-Quirós, A., Martínez-Gallo, M., Ruiz-Sanmartín, A., del Campo, Á. G., Ferrer-Roca, R., Ruiz-Rodriguez, J. C., Álvarez-Errico, D., López-Collazo, E., & Ballestar, E. (2019). Inflammatory cytokines and organ dysfunction associate with the aberrant DNA methylome of monocytes in sepsis.
Genome Medicine, 2019, oct 11(1), 66.
doi.org/10.1186/s13073-019-0674-2
IF: 10.89Rudilla F, Franco-Jarava C, Martínez-Gallo M, Garcia-Prat M, Martín-Nalda A, Rivière J, Aguiló-Cucurull A, Mongay L, Vidal F, Solanich X, Irastorza I, Santos-Pérez J L, Tercedor Sánchez J, Cuscó I, Serra C, Baz-Redón, N, Fernández-Cancio M, Carreras C, Vagace JM, Garcia-Patos V, Pujol-Borrell R, Soler-Palacin P, Colobran R.
Expanding the Clinical and Genetic Spectra of Primary Immunodeficiency-Related Disorders With Clinical Exome Sequencing: Expected and Unexpected Findings.
Frontiers in Immunology, 2019 10 (Oct), 2325
doi.org/10.3389/fimmu.2019.02325
IF: 4.72
Álvarez-Sierra D, Marín-Sánchez A, Ruiz-Blázquez P, de Jesús Gil C., Iglesias-Felip C., González, Ó, Casteras A., Costa RF, Nuciforo P, Colobran R, Pujol-Borrell, R.
Analysis of the PD-1/PD-L1 axis in human autoimmune thyroid disease: Insights into pathogenesis and clues to immunotherapy associated thyroid autoimmunity.
Journal of Autoimmunity, 2019 Sep: 103, 102285.
10.1016/j.jaut.2019.05.013
IF: 7.54
Marín-Sánchez A, Álvarez-Sierra D, González, O, Lucas-Martin A., Sellés-Sánchez A, Rudilla F, Enrich E, Colobran R, & Pujol-Borrell R. (2019). Regulation of TSHR Expression in the Thyroid and Thymus May Contribute to TSHR Tolerance Failure in Graves’ Disease Patients via Two Distinct Mechanisms.
Frontiers in Immunology, 2019 July: 10, 1695.
doi.org/10.3389/fimmu.2019.01695
IF: 4.72

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Immunomediated Diseases and Innovative Therapies

Overview

Publications

Group Leader: Ricardo Pujol Borrell

Research Areas