Neurosciences

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Overview

The Neuroscience area is consolidating its position as one of the largest clusters of research labs working on neurological diseases across Europe. At present, the area comprises 14 groups with more than one hundred fully dedicated researchers in close contact with top clinicians in the hospital. These research groups pursue a better and multifaceted understanding of the etiopathogenic mechanisms underlying a large variety of mostly adult but also pediatric neurological disorders including stroke, multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, primary headaches, epilepsy, neuromuscular disorders, and also neurosurgical and psychiatric pathologies. The area also integrates groups involved in neuroimaging, analysis and interpretation of high-throughput data, and gene therapy strategies to target inflammatory and neurodegenerative neurological conditions.

Publications

276
total
1952
impact factor
7.07
average impact factor

Group Leader: Alfons Macaya Ruiz

In 2019 the Pediatric Neurology group remained commited to clinical trials in Pediatric Rare Neurological Diseases, including active ones with small molecule and advanced therapies for Duchenne muscular dystrophy, spinal muscular atrophy, pantotenate-kinase associated neurodegeneration and several lysosomal storage disorders. This prompted, among other, the rewarding result of normal neurodevelopment in the first SMA Spanish patient treated presymptomatically with antisense oligonucleotides. Four members of the group are representatives at three European Reference Networks and coordinate working groups thereof. Research in neurogenetics has helped identifying three novel genes for developmental and epileptic encephalopathies and for congenital myasthenia in collaboration with international partners. The group has contributed significantly to two important projects dealing with undiagnosed rare disorders, using a deep phenotyping plus multi-omics approach: Solve-RD and URD-Cat.

VHIR Annual Report 2019